間質性膀胱炎（慢性膀胱炎）または膀胱痛症候群の患者に対する水素水摂取の効果 | Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome.

Urology. 2013 Feb;81(2):226-30. doi: 10.1016/j.urology.2012.10.026.

Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome.

Matsumoto S, Ueda T, Kakizaki H.

Source

Department of Renal and Urologic Surgery, Asahikawa Medical University, Hokkaido, Japan. matsums@asahikawa-med.ac.jp

Abstract

OBJECTIVE:

To investigate the efficacy of hydrogen-rich water for the treatment of patients with interstitial cystitis/painful bladder syndrome (IC/PBS).

METHODS:

We conducted a prospective, randomized, double-blind, placebo-controlled clinical trial of hydrogen-rich water in patients with IC/PBS. Inclusion criteria were stable symptoms of IC/PBS for ≥ 12 weeks after bladder hydrodistension, Interstitial Cystitis Symptom Index score of ≥ 7 and bladder pain (question 4 on Interstitial Cystitis Symptom Index) of ≥ 4. They were randomized by a 2:1 ratio to receive hydrogen-rich water or placebo water for 8 weeks. The symptoms were assessed using the Interstitial Cystitis Symptom Index, Interstitial Cystitis Problem Index, Parsons’ Pelvic Pain and Urgency/Frequency Patient Symptom Scale, visual analog scale bladder pain scores, and a standard 3-day voiding diary. The primary outcome was improvement of patient-reported symptoms evaluated after treatment.

RESULTS:

A total of 30 participants (29 women and 1 man, age 64.0 ± 14.8 years) were enrolled in the present study, and 2 patients (both women) were withdrawn from the study. The score of bladder pain was significantly reduced in both groups. However, the effect of hydrogen-rich water on symptoms was not significantly different from that of placebo, although supplementation with hydrogen-rich water was extremely effective in improving the bladder pain score in 11% of the patients.

CONCLUSION:

The results of the present study do not support the use of supplementation with hydrogen-rich water for treating patients with IC/PBS.

Urology. 2013 Feb;81(2):226-30. doi: 10.1016/j.urology.2012.10.026

間質性膀胱炎（慢性膀胱炎）または膀胱痛症候群の患者に対する
水素水摂取の効果

旭川医科大学腎泌尿器外科学講座

＜要旨＞

目的

間質性膀胱炎または膀胱痛症候群の患者に対する水素水の摂取効果を調べるため

方法

間質性膀胱炎または膀胱痛症候群（ＩＣ/ＰＢＳ）の患者に水素水を摂取してもらう臨床試験を、前向き無作為プラセボ対照二重盲検で行いました。対象には、膀胱水圧拡張術後12週間以上ＩＣ/ＰＢＳの症状が安定しており、間質性膀胱炎症状スコア（ＩＣＳＩ）が７以上、膀胱痛が4以上（ＩＣＳＩ設問4による）を選びました。そして被験者を2：1の比で水素水摂取群とプラセボ水摂取群にランダムにわけ、8週間摂取してもらいました。

また、膀胱炎の症状は以下を使って評価しました。
ＩＣＳＩ、間質性膀胱炎問題スコア（ＩＣＰＩ）、膀胱痛に対する視覚的評価スケール、ＰＵＦ症状スコア（骨盤痛、尿意切迫感、頻尿）、3日間排尿日誌

なお症状改善に関する主な評価項目は、摂取期間後の患者の評価報告にしました。

結果

30名の被験者（男性1人、女性29人、64.0±14.8歳）が本研究に登録し、そのうちの2名（いずれも女性）が辞退しました。膀胱痛の値は両群で有意に低下しており、また、水素水摂取群の効果はプラセボ水摂取群と比べ、有意な差はありませんでした。しかしながら水素水を摂取した患者の11％は、膀胱痛が著しく改善しました。